Preserving Life by Emulating Nature
A robust preservation platform for cells, tissues, organs, and regenerative medicines.
We advance regenerative medicine and organ transplantation with a ground-breaking biopreservation platform. We enable safe and reliable organs, engineered tissues, and cell therapies to patients in need and break down the barriers of time and distance.
You have Time.
Organ Transplant
Not Enough Time
Do you know 80% of transplantable organs end up NOT being transplanted today, especially for hearts and lungs?
90%
1/hour
Die on waitlist
80%
transplantable organs wasted
Just hours
to keep organs alive
In organ transplantation, we are racing against TIME on Ice every day, battling an extremely slim window where every minute matters. We currently perfuse and store an organ in preservation solution that is kept between 2-8°C in an igloo cooler on wet-ice. This only allows organ survival for less than a day. For the heart, that is an ephemeral 4 hrs. This extremely tight race severely hinders organ accessibility, breeds extreme risk, creates a logistics nightmare for the transplant team and significantly impacts patient survival.
To win such a race, we MUST remove TIME from the equation.
cGMP CELL & GENE THERAPY
DMSO and Serum No Longer Meet Integrated Demands
- Poor post-thaw cell survival as low as 15-20%
- Cell functionality impaired
- Profound in vivo toxicity
- Severe injection site pain/neurotoxicity
- Adverse Genotoxicity
Nature, Scientific Reports volume 9, Article number: 4641 (2019)
- Processing nightmare
- Limited scale-up production
- Batch variation
Biopreservation is the key for commercial cell manufacturing & processing, which happens 3-5 times throughout the process. However, preservation has seen little improvement. Existing standards use 5-10% dimethyl sulfoxide (DMSO) with serum. A new solution is needed to enable “off-the-shelf” living medicines.
In Vitro Fertilization
Can we say “No” to toxins for healthy babies?
DMSO
Adverse Toxicity & Genotoxicity
Poor Functional Recovery <10% (human eggs)
In Vitro Fertilization uses a high concentration of toxic vitrification media to freeze eggs or embryos that can kill a cat just in one teaspoon taken orally. This causes severe cell shrinkage and damage to the cell membrane, ultimately leading to a negative impact on the viability of the eggs, giving less than 10% with functional recovery.
The extreme changes in microRNAs and alterations in the epigenetic landscape indicate that DMSO is not inert. Its use should be reconsidered, especially for preservation of embryos and oocytes, since it may impact embryonic development.
Nature, Scientific Reports volume 9, Article number: 4641 (2019)
Organ Transplant
Not Enough Time
Do you know 80% of transplantable organs end up NOT being transplanted today, especially for hearts and lungs?
90%
1/hour
Die on waitlist
80%
transplantable organs wasted
Just hours
to keep organs alive
In organ transplantation, we are racing against TIME on Ice every day, battling an extremely slim window where every minute matters. We currently perfuse and store an organ in preservation solution that is kept between 2-8°C in an igloo cooler on wet-ice. This only allows organ survival for less than a day. For the heart, that is an ephemeral 4 hrs. This extremely tight race severely hinders organ accessibility, breeds extreme risk, creates a logistics nightmare for the transplant team and significantly impacts patient survival.
To win such a race, we MUST remove TIME from the equation.
"Look deep into nature, and then you will understand everything better. "
-Albert Einstein
Arctic fish thrive in sub-zero environments because of Antifreeze Proteins (AFPs) that reduce the freezing point of water and bind nucleated ice to control the growth of lethal ice crystals. Inspired by AFPs, we developed a chemically defined antifreeze molecule that is hyper effective, non-toxic, biocompatible, and scalable.
XT-Thrive®
Chemically Defined Safe & Effective Cryopreservation
XT-Thrive® is a DMSO-free, serum-free, protein-free, and chemically defined cryopreservation media for the preservation of mammalian cells at ultra-low temperatures (-70° C to -196° C). It is a non-toxic & hyper-effective alternative to DMSO and serum products. It is plug and play for cell & tissue manufacturing processes.
XT-ViVo®
Organ and Tissue Preservation Solution
XT-ViVo® is a novel subzero preservation solution that will enable safe long-term ice-free storage and transport for tissues and organs. XT-ViVo® has been designated as a Breakthrough Device by the FDA.
